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Mammoth Biosciences’s CRISPR-based COVID-19 test receives NIH funding through RADx program – TechCrunch

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Mammoth Biosciences’s CRISPR-based COVID-19 test receives NIH funding through RADx program – TechCrunch

CRISPR tech startup Mammoth Biosciences is among the many corporations that exposed backing from the National Institutes of Health (NIH) Rapid Acceleration of Diagnostics (RADx) program on Friday. Mammoth acquired a contract to scale up its CRISPR-based SARS-CoV-2 diagnostic take a look at in an effort to assist handle the testing shortages throughout the U.S.

Mammoth’s CRISPR-based method might doubtlessly supply a big answer to present testing bottlenecks, as a result of it’s a really completely different form of take a look at when in comparison with current strategies primarily based on PCR know-how. The startup has additionally enlisted the assistance of pharma large GSK to develop and produce a brand new COVID-19 testing answer, which can be a handheld, disposable take a look at that may supply leads to as little as 20 minutes, on web site.

While that take a look at remains to be in growth, the RADx funding acquired by this funding can be used to scale manufacturing of the corporate’s DETECTR platform for distribution and use in industrial laboratory settings. This will nonetheless supply a “multi-fold improve in testing capability,” the corporate says, despite the fact that it’s a lab-based answer as an alternative of a point-of-care take a look at just like the one it’s looking for to create with GSK.

Already, UCSF has acquired an Emergency Use Authorization (EUA) from the FDA to make use of the DETECTR reagent set to check for the presence of SARS-CoV-2, and the startup hopes to have the ability to lengthen comparable testing capability to different labs throughout the U.S.

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Five success factors for behavioral health startups – TechCrunch

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Five success factors for behavioral health startups – TechCrunch

Courtney Chow
Contributor

Courtney Chow is an affiliate with Battery Ventures in San Francisco who focuses on early and growth-stage web, software program and companies firms.

Justin Da Rosa
Contributor

Justin Da Rosa is a vp with Battery Ventures in San Francisco. He focuses on client web, on-line market and software program investments.

Telehealth, or distant, tech-enabled healthcare, has existed for years in major medical care by means of firms like Teladoc (NYSE: TDOC), Doctors on Demand and MDLIVE.

In current years, the appliance of telehealth had quickly expanded to handle particular power and behavioral well being points like psychological well being, weight reduction and diet, dependancy, diabetes and hypertension, and so forth. These are actual and oftentimes very extreme points confronted by individuals all around the world, but till now have seen little to no use of know-how in offering care.

We consider behavioral well being is especially suited to profit from the digitization traits COVID-19 has accelerated. Previously, we’ve written concerning the pandemic’s influence on on-line studying and schooling, each for Ok-12 college students and grownup learners. But behavioral well being is one other space impacted by the basic change in shoppers’ conduct at the moment. Below are 4 causes we expect the time is now for behavioral well being startups — adopted by 5 key components we expect characterize profitable firms on this space.

Telehealth can considerably decrease the price of care

Traditional behavioral healthcare is cost-prohibitive for most individuals. In-person remedy prices $100+ per session within the U.S., and plenty of psychological well being and substance-use suppliers don’t settle for insurance coverage as a result of they don’t receives a commission sufficient by insurers.

By distinction, telehealth reduces overhead prices and scales extra successfully. Leveraging know-how, suppliers can deal with extra sufferers in much less time with nearly zero marginal prices. Mobile-based communications allow asynchronous care that additional helps suppliers scale. Access to digital content material provides sufferers on-going assist with out the necessity for a human on the opposite aspect. This is especially helpful in treating behavioral well being points the place ongoing assist and motivation could also be needed.

Technology unlocks provide in “shadow markets” of suppliers

Globally, we face an excessive scarcity of behavioral well being suppliers. For instance, the United States has fewer than 30,000 licensed psychiatrists (translating to <1 for each 10,000 individuals). Outside of massive cities, the issue will get worse: ~50-60% of nonmetro counties haven’t any psychologists or psychiatrists in any respect.

Even when suppliers can be found, wait instances for appointments are notoriously lengthy. This is a big concern when behavioral well being situations usually require well timed intervention.

We are seeing new platforms construct massive networks of licensed coaches, licensed psychologists and psychiatrists, and different suppliers, aggregating provide in what has traditionally been a scarce and a extremely fragmented supplier inhabitants.

Behavioral/psychological well being points are dropping their stigma

We consider the stigma related to psychological sickness and different behavioral well being situations is dissipating. More and extra public figures are talking out about their battle with nervousness, melancholy, dependancy and different behavioral well being points. Our zeitgeist is shifting quick, and there’s an all-time excessive in individuals searching for assist because the Google Trends information beneath demonstrates.

Image Credits: Google

Note: The anomalous dip in March/April ’20 was pushed by necessary shelter-in-place as a result of COVID-19.

Policy and rules are altering rapidly

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Instagram wasn’t removing photos and direct messages from its servers – TechCrunch

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Instagram wasn’t removing photos and direct messages from its servers – TechCrunch

A safety researcher was awarded a $6,000 bug bounty payout after he discovered Instagram retained photographs and personal direct messages on its servers lengthy after he deleted them.

Independent safety researcher Saugat Pokharel discovered that when he downloaded his information from Instagram, a characteristic it launched in 2018 to adjust to new European information guidelines, his downloaded information contained photographs and personal messages with different customers that he had beforehand deleted.

It’s not unusual for corporations to retailer freshly deleted information for a time till it may be correctly scrubbed from its networks, methods and caches. Instagram stated it takes about 90 days for deleted information to be absolutely faraway from its methods.

But Pokharel discovered that his ostensibly deleted information from greater than a 12 months in the past was nonetheless saved on Instagram’s servers, and may very well be downloaded utilizing the corporate’s information obtain device.

“Instagram didn’t delete my information even once I deleted them from my finish,” he informed TechCrunch .

Pokharel reported the bug in October 2019 by Instagram’s bug bounty program. The bug was fastened earlier this month, he stated.

A spokesperson for Instagram informed TechCrunch: “The researcher reported a problem the place somebody’s deleted Instagram photos and messages can be included in a replica of their data in the event that they used our Download Your Information device on Instagram. We’ve fastened the problem and have seen no proof of abuse. We thank the researcher for reporting this subject to us.”

It’s a near-identical subject that Twitter fastened final 12 months, by which customers may entry long-deleted direct messages — together with messages despatched to and from suspended and deactivated accounts — utilizing its personal information obtain device.

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Impossible Foods gobbles up another $200 million – TechCrunch

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Impossible Foods gobbles up another $200 million – TechCrunch

Impossible Foods has raised $200 million extra for its meat replacements.

The new spherical values the corporate at a Whopper-sized $four billion valuation, in line with the info tracker PrimeUnicorn Index.

The new spherical was led by Coatue, a technology-focused hedge fund; one other New York-based hedge fund, XN, additionally participated within the spherical.

Since its launch the corporate has raised $1.5 billion from traders, together with Mirae Asset Global Investments and Temasek. The presence of those new public/non-public funding corporations on Impossible Foods’ cap desk may imply that the corporate is readying itself for an preliminary public providing, however that’s simply hypothesis.

Impossible beforehand raised cash from funding corporations together with Horizon Ventures and Khosla Ventures, in addition to a number of the largest celebrities within the U.S., like: Jay Brown, Common, Kirk Cousins, Paul George, Peter Jackson, Jay-Z, Mindy Kaling, Trevor Noah, Alexis Ohanian, Kal Penn, Katy Perry, Questlove, Ruby Rose, Phil Rosenthal, Jaden Smith, Serena Williams, will.i.am and Zedd.

The most up-to-date value per share is $16.15, an up spherical from Series F at $15.4139, in line with PrimeUnicorn.

The firm mentioned it might use the funding to extend its analysis and growth efforts and work on new merchandise like pork, steak and milk, in addition to broaden its internationalization efforts and construct out its manufacturing capability.

“The use of animals to make meals is essentially the most damaging expertise on Earth, a number one driver of local weather change and the first explanation for a catastrophic international collapse of wildlife populations and biodiversity,” mentioned the extremely credentialed Dr. Patrick O. Brown, MD, PhD, CEO and founding father of Impossible Foods, in a press release. “Impossible Foods’ mission is to exchange that archaic system by making essentially the most scrumptious, nutritious and sustainable meats on the earth, straight from crops. To try this, Impossible Foods must maintain our exponential progress in manufacturing and gross sales, and make investments considerably in R&D. Our traders imagine in our mission to rework the worldwide meals system — and so they acknowledge a unprecedented financial alternative.”

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